• Bioprospecting of marine fungi from the High Arctic: A study of high latitude marine fungi from understudied taxa; bioactivity potential, taxonomy and genomics 

      Hagestad, Ole Christian (Doctoral thesis; Doktorgradsavhandling, 2021-06-17)
      Marine fungi comprise a group of organisms that have been overlooked for a long time. Research interest has increased with the realization of the important ecological role and rich chemistry of marine fungi. Marine fungi have yielded thousands of new natural products the last decade, but many taxa remain unstudied. Marine fungi from the Arctic have not been reported in literature in regard to ...
    • Cultivable marine fungi from the Arctic Archipelago of Svalbard and their antibacterial activity 

      Hagestad, Ole Christian; Andersen, Jeanette hammer; Altermark, Bjørn; Hansen, Espen; Rämä, Teppo (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-27)
      During a research cruise in 2016, we isolated fungi from sediments, seawater, driftwood, fruiting bodies, and macroalgae using three different media to assess species richness and potential bioactivity of cultivable marine fungi in the High Arctic region. Ten stations from the Svalbard archipelago (73–80 °N, 18–31 °E) were investigated and 33 fungal isolates were obtained. These grouped into 22 ...
    • Enterococcus faecium produces membrane vesicles containing virulence factors and antimicrobial resistance related proteins 

      Wagner, Theresa; Joshi, Bishnu; James Peter, Jessin Janice; Askarian, Fatemeh; Skalko-Basnet, Natasa; Hagestad, Ole Christian; Mekhlif, Ahmed; Wai, Sun Nyunt; Hegstad, Kristin; Johannessen, Mona (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-05-30)
      <i>Enterococcus faecium</i> is a commensal but also a bacteremia causing pathogen, which is inherently resistant to several antimicrobials and has a great ability to acquire new traits. Bacterial membrane vesicles (MVs) are increasingly recognized as a mode of cell-free communication and a way to deliver virulence factors and/or antimicrobial resistance determinants. These features make MVs interesting ...
    • Genomic characterization of three marine fungi, including Emericellopsis atlantica sp. nov. with signatures of a generalist lifestyle and marine biomass degradation 

      Hagestad, Ole Christian; Hou, Lingwei; Andersen, Jeanette Hammer; Hansen, Espen; Altermark, Bjørn; Li, Chun; Kuhnert, Eric; Cox, Russell J.; Crous, Pedro W.; Spatafora, Joseph W.; Lail, Kathleen; Amirebrahimi, Mojgan; Lipzen, Anna; Pangilinan, Jasmyn; Andreopoulos, William; Hayes, Richard H.; Ng, Vivian; Grigoriev, Igor V.; Jackson, Stephen A.; Sutton, Thomas D. S.; Dobson, Alan D. W.; Rämä, Teppo (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-09)
      Marine fungi remain poorly covered in global genome sequencing campaigns; the 1000 fungal genomes (1KFG) project attempts to shed light on the diversity, ecology and potential industrial use of overlooked and poorly resolved fungal taxa. This study characterizes the genomes of three marine fungi: <i>Emericellopsis</i> sp. TS7, wood-associated <i>Amylocarpus encephaloides</i> and algae-associated ...
    • Selective isolation of Arctic marine actinobacteria and a down-scaled fermentation and extraction strategy for identifying bioactive compounds 

      Schneider, Yannik Karl Heinz; Hagestad, Ole Christian; Li, Chun; Hansen, Espen Holst; Andersen, Jeanette Hammer (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-21)
      Actinobacteria are among the most prolific producers of bioactive secondary metabolites. In order to collect Arctic marine bacteria for the discovery of new bioactive metabolites, actinobacteria were selectively isolated during a research cruise in the Greenland Sea, Norwegian Sea and the Barents Sea. In the frame of the isolation campaign, it was investigated how different sample treatments, isolation ...